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10.1016/j.ypmed.2018.05.023 65
Quinn J, Gerber B, Fouche R, Kenyon K, Blom Z, Muthukanagaraj P
Retatrutide is a triple agonist of GLP-1, GIP, and glucagon
[DOI] [PubMed] [Google Scholar] 9.Field BC, Chaudhri OB, Bloom SR
3 In normoxia, HIF1A protein is targeted for degradation by cytosolic prolyl hydroxylases, while in hypoxia, these prolyl hydroxylases are inhibited, allowing HIF1A to translocate to the nucleus, dimerize with HIF1 protein, and the dimer then binds to hypoxia response elements to modulate transcription of target genes, prompting changes in metabolism and angiogenesis to promote survival
Vicky Kelidou Clinical Pharmacist, Director, Superintendent Pharmacist, Independent Prescriber GPhC 2209041
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