10.1080/03602530600952172 16 SharmaR.McDonaldT
Beyond the ENS, this transcriptional factor when selectively activated by the microbial metabolite indole produced by tryptophanase-expressing gut microbes interestingly induces neurogenic effects in the adult murine hippocampus as identified by elevated expression of -catenin, Neurog2, and VEGF- (Wei et al., 2021)
These compelling findings have positioned MOTS-c as an exciting focus of study in the fields of metabolic disease and geroscience
They help nerves produce energy and maintain myelin, the protective covering around nerve fibers
facility and formulated for up to 92% bioavailability
The critical role of NAD+ in neuronal function and brain health has made it a central focus of neurodegenerative disease research, with extensive evidence indicating that NAD+ depletion contributes to pathological processes in animal models of Alzheimer's disease, Parkinson's disease, Huntington's disease, and other neurodegenerative conditions