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Skin consists of specialized cells known melanocytes

Laboratory and animal studies suggest GLP-1 receptor agonists may also inhibit nuclear factor-kappa B (NF-B) signaling, a key pathway in inflammatory gene expression, and reduce oxidative stress through enhanced antioxidant enzyme activity

It has been shown that hypoxia can stimulate ROS production in mitochondria, which activates hypoxia-inducible transcription factor 1 alpha (HIF1) [4]