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Generally, introducing positively charged residues at the N- or C-terminus of peptides that do not affect the interactions is the commonly used method to enhance cell permeability

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Effects of glucagon-like peptide-1 receptor agonists on cardiovascular outcomes in high-risk type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

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Geopolitics also pose a threat

In healthy adult individuals, 90% of the intestinal bacteria belong to 2 phyla: Bacteroidetes and Firmicutes