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It is localized in the mitochondria and constitutes cca 15% of the total superoxide dismutases

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Moreover, its expression appears to be influenced by metabolic stress, with it being increased in islets from diet-induced obese mice compared to normal weight animals (104), but lower in human islets from diabetic compared to non-diabetic donors (98, 99, 104)

Clin Sci (Lond) 106:235237

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They identified 35 eligible studies, including 31 preclinical models of cerebral ischemia and 4 clinical studies in patients with nondiabetic ischemic stroke