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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy
Last reviewed: July 16, 2026 Last updated: July 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
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Bull Exp Biol Med 2001;131:3946
It is frequently used to lower the risk of major cardiovascular events in adults with type 2 diabetes who have existing heart disease or risk factors
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