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studied IC/BPS patients with Hunner lesions and abnormal bladder biopsy results (including histopathologic findings of inflammatory infiltrates, granulation tissue, overexpression of mast cells, and/or intrafascicular fibrotic changes), also called ESSIC type 3C disease ( Box 35.2 ), and compared them to IC/BPS patients with normal cystoscopy and biopsy results

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The platelet pellet was resuspended in 13 mL of the participants own plasma by gentle pipetting to obtain a highly enriched PRP

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Both medications have been reported to show little or no change in pharmacokinetics and pharmacodynamics in patients with RI versus those with normal renal function, are well-tolerated, and exhibit a low risk of hypoglycemia, irrespective of renal function [24, 25, 29, 30]