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Notably, participants in key clinical trials experienced significantly greater weight loss compared to placebo groups, with some individuals losing more than 15% of their initial body weight

After four weeks, the dose may increase to 0.5 mg once a week, depending on how the person feels

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Month 4 (1.7 mg): Weight loss tends to continue at a steady pace for most patients

Few studies stratify participants by biological signatures such as mitochondrial phenotypes, redox profiles, or folate receptor alpha autoantibodies, even though data indicate differential responsiveness to targeted interventions in defined endophenotypes (Frye et al., 2024

Dinner portions are usually small but manageable