Proper labeling avoids mistakes
Since isolated primary human islets cannot be cultured for extensive periods of time and exhibit donor-to-donor variability, most groups have historically relied on rodent models and cell lines to robustly understand the genetic and mechanistic components involved in the initiation and progression of T1D
These comparator categories were prespecified to keep comparisons clinically meaningful and to avoid pooling different control types that could blur ALCs added effect
A critical Review
Fahrmann JF, Schmidt CM, Mao X, Irajizad E, Loftus M, Zhang J, Patel N, Vykoukal J, Dennison JB, Long JP et al
The TCF7L2 Gene: Your GLP-1 Regulator The TCF7L2 gene is a GLP-1 regulator and its important because it: Directly regulates the production and secretion of GLP-1 Influences how well GLP-1 can stimulate insulin release Its strongly linked to type 2 diabetes risk (the strongest genetic risk factor identified!) When you have certain variants of TCF7L2, your body produces less GLP-1 and responds more weakly to the GLP-1 you do produce
