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10.1371/journal.pone.0081640 176 YangL

Schleicher U, Paduch K, Debus A, Obermeyer S, Konig T, Kling JC, et al

The FDA also warns that there are no injectable products approved to lighten the skin

It is unique because it can pass through the mitochondria and enter the nucleus of the cell, where it activates signals that promote normal metabolic homeostasis of glucose and lipid metabolism

Norleual-AngIV was used to inhibit HGF binding to the c-Met receptor, consequently blocking HGF-dependent signaling pathways involved in proliferation, invasion, and scattering

The inhibitors designed to target one specific isoform may inadvertently affect others, causing unintended interactions or side effects and complicating their therapeutic use