Side note: the same receptor strongly increases appetite
GCG agonism provides direct hepatic effects by inhibiting lipogenesis and promoting fat oxidation while augmenting energy expenditure
This can be done at home or under medical supervision
When to Delay Dose Escalation Hold your current retatrutide dose and don't escalate if you experience: Persistent nausea or vomiting (more than 3 days after injection) Severe constipation or diarrhea Significant injection site reactions Rapid weight loss (more than 3-4 lbs/week consistently) Signs of dehydration from GI symptoms It's acceptable to remain at a dose longer than 4 weeks if needed
Ivm Health currently offers multiple options including brand name Wegovy, Zepbound, Wegovy Pill, as well as compounded semaglutide and compounded tirzepatide as injectable options with individualized dosing and ongoing support from your care team
Surgical Options: In cases of severe obesity, surgical procedures like gastric bypass, gastric sleeve, or lap band surgery may be considered a last resort