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Common side effects may include: Nausea Mild digestive upset Temporary fatigue These symptoms typically subside as your body adjusts

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The B12 deficiency can be the unrecognised reason for your exhaustion

Last reviewed: June 4, 2026 Last updated: June 4, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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doi:10.1021/acs.orglett.6b02611