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A phase 2 randomized controlled trial of personalized peptide vaccine immunotherapy with low-dose dexamethasone versus dexamethasone alone in chemotherapy-naive castration-resistant prostate cancer

A 2019 review in Hormone and Metabolic Research documented these outcomes, while the landmark STEP 1 trial (Wilding et al., NEJM 2021) established 14.9% average weight reduction with semaglutide with direct relevance to androgen-driven conditions where adipose tissue is itself a hormonal organ

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PubMed Rockenstein, E., Torrance, M., Mante, M., Adame, A., Paulino, A., Rose, J.B., Crews, L., Moessler, H., & Masliah, E