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Many breast cancer treatments, particularly certain chemotherapy regimens and hormonal therapies like tamoxifen or aromatase inhibitors, can contribute to weight gain and metabolic syndrome, making diabetes management more complex
Increased utilization of NADPH for fatty acid biosynthesis will dramatically increase the level of NADP + , thus stimulating G6PD to produce more NADPH
The primary antibodies used are as follows: anti-ABCA1 (1:500, ab18180, Abcam, Cambridge, United Kingdom), anti-PARP-1 (1:1000, 13371-1-AP, Proteintech, Wuhan, China), anti-p-PARP-1 (1:1000, MBS9206900, MyBioSource, San Diego, CA, United States), anti-LXR (1:500, ab176323, Abcam), anti-AMPK (1:1000, 10929-2-AP, Proteintech), anti-p-AMPK (1:1000, ab133448, Abcam)
