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In clinical trials, GI side effects occur in roughly 4050% of patients on either medication, though they are typically mild to moderate and tend to improve over the first 812 weeks

1.3 Therapeutic Classification and Clinical Significance Semaglutide belongs to the incretin mimetic class, specifically GLP-1 receptor agonists

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Regulatory implications: These differences formed the basis of Novo Nordisks formal petition nominating semaglutide for the FDAs Demonstrable Difficulties for Compounding (DDC) lists arguing that the complexity of replicating recombinant semaglutide through synthetic compounding makes it inherently unsuitable for routine compounding

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Kandpal et al., 2022)