Retatrutide, a triple-agonist (GLP-1, GIP and glucagon), is in late-stage trials and has produced even more weight loss in early data up to 24% at 48 weeks in phase 2
Whilst standard therapeutic doses of semaglutide or liraglutide are carefully calibrated through extensive clinical trials, microdosing involves using a fraction of these established dosesoften below licensed starting doses
However, the lack of efficacy of GIP agonists in stimulating insulin secretion and promoting glucose disposal in individuals with type 2 diabetes [6, 7] raises doubts about whether both GLP-1 and GIP mediate the therapeutic effects of DPP-4 inhibitors in humans [8]
In other words: signs of active cellular repair
Eli Lily and Company) 39 2022 8 2
BPC-157 (Body Protection Compound-157) is a synthetic gastric pentadecapeptide that has demonstrated significant tissue repair activity across preclinical models