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Patients with Renal Impairment In adult patients with type 2 diabetes mellitus with mild (eGFR: 60 to less than 90 mL/min/1.73 m2), moderate (eGFR: 30 to less than 60 mL/min/1.73 m2), and severe (eGFR: less than 30 mL/min/1.73 m2) renal impairment and patients on dialysis due to kidney failure, AUC of empagliflozin increased by approximately 18%, 20%, 66%, and 48%, respectively, compared to subjects with normal renal function

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At 80 milligrams (mg) of caffeine per cup, yerba mate contains about the same amount of caffeine as a cup of coffee

Annual Review of Nutrition, 43, 301-325.

4 Autoimmune Neuropathies In experimental autoimmune neuritis, ARA-290 has shown efficacy in suppressing inflammation and promoting nerve regeneration without inducing hematopoiesis, making it a candidate for treating autoimmune neuropathies