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No significant systemic copper elevation has been reported from topical application in healthy adults

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

doi: 10.1053/j.gastro.2018.11.029 161 SzczeklikKKrzyciakWCiborDKozioKPocztarHPytko-PoloczykJet al

Acyl-Glutathione is the body's main antioxidant that works as a natural building block to help replenish fragile skin and reduce the look of wrinkles

It is intricately associated with metabolic dysfunctions linked to obesity and demonstrates a bidirectional connection with various comorbidities (271, 272)

10.1038/s41398-025-03372-w 304 MakkawiS.Camara-LemarroyC.MetzL