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IpsenDHRolinBRakipovskiGSkovstedGFMadsenAKolstrupSet al

A Phase 2 Study of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients With Rheumatoid Arthritis Inadequately Responding to Biological Disease-Modifying Antirheumatic Drugs

9799 In one study, the activation of genes associated with oxidative damage, including NQO1 and HMOX1, due to vaped VEA was larger than from duroquinone alone, 100 indicating that duroquinone may not be the only contributor to the adverse effects of VEA

Fortunately, most are mild to moderate and tend to improve over time

All enrolled patients had not received any drug treatment or irradiation therapy prior to sample collection

A few hepatocytes may contain one or more smaller vacuoles