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In particular, reduced GST activity as compared to control subjects was described in all brain areas and ventricular CSF in postmortem AD patients, suggesting a role of these enzymes in the pathogenesis of the disease 51

Cerebellar abnormalities have also been reported in several psychic disorders, such as autism spectrum disorders, schizophrenia or post-traumatic stress disorder [6, 9, 12, 210,211,212,213,214]

Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development

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doi: 10.1042/bj3360535