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Loss of DPEP1 markedly relieved FA- or cisplatin-induced AKI by altering the apoptosis and ferroptosis, but not the pyroptosis or necroptosis

This is not an uncommon story

Tirzepatide, a dual GLP-1 and GIP receptor agonist, has demonstrated average weight loss of 22% in clinical trials when delivered by injection

We also conducted an as treated analysis assessing only active treatment from first initiation until first break of treatment, where cohort members were followed from index date until first registration of suicide or suicide attempts, emigration, death, switching to the other study drug or reaching the end of their first treatment period

Moreover, similarly to the dual GIPR/GLP-1R agonist, LY3437943 reduced blood glucose and plasma insulin, suggesting potential improvements in insulin sensitivity