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But its also part of a bigger system: the balance between free carnitine, acylcarnitines, and acyl-CoA, a trade-off game that helps regulate how different substrates are handled inside the cell

19 Following further translocation to the mitochondria, activated phosphorylated JNK initiates a cascade in which JNK binds to the outer mitochondrial membrane scaffold protein Sab, inhibiting electron transport and thereby increasing the generation of ROS and peroxynitrite

For the genome-scale screen we generated a CRISPR sgRNA containing 84,155 sgRNAs targeting 21,039 protein-coding genes, with 4 sgRNAs designed per each gene

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