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In 2013, a clinical trial comparing phentermine as monotherapy or as part of a combined therapy, took place and resulted in a weight loss of 5.1% at 28 weeks follow-up period in favor of the combined phentermine/topiramate group.(see Table 10) Table 10

97 An increased prevalence of proliferative retinopathy is also observed in patients with acromegaly

It modulates muscle lipases

A deficiency in vitamin B12 results in an insufficiency of mature red blood cells containing haemoglobin, the oxygen carrying pigment that distributes oxygen to all the tissues around the body

Disruption in GSH homeostasis has been linked to initiation and progression of neurodegenerative diseases

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