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Burrell LM, Johnston CI, Tikellis C, Cooper ME

This work was partially supported by National Natural Science Foundation of China 81872915 (MWW), 82073904 (MWW), 81773792 (DHY) and 81973373 (DHY)

Small molecule drugs Currently, there are 2 small molecule drugs targeting GCGR in clinical development: PegBios GCGR -only agonist PB-722 and the Tianjin Instituteof Pharmaceutical Researchs GCGR x GLP-1R dual agonist TY-751.Bothof these drugs have had their clinical trial applications accepted for review

Acta endocrinologica (Bucharest, Romania : 2005), 18 (2), 216224

Quercetin (pentahydroxy flavone), a natural flavonoid, could up-regulate the GSH levels and inhibit ferroptosis by reducing MDA and lipid ROS levels in the renal proximal tubular epithelia 513