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Bern, M., Sand, K

Peak appetite reduction occurs around week 12 when reaching maintenance dose

GIP lacks this effect

Early clinical trials evaluating the efficacy of GLP-1 receptor agonists reported a slightly increased risk of acute pancreatitis with these medications versus placebo or conventional treatment

In the nonalcoholic steatohepatitis (NASH) model, BN can reduce liver weight and steatosis and improve insulin sensitivity

The increase was modest and did not produce clinical events in the trial population, but researchers with pre-existing cardiovascular conditions should factor this into their risk assessment