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Untreated obesity increases the risk of cardiovascular disease, type 2 diabetes, obstructive sleep apnea, metabolic-associated steatotic liver disease (fatty liver), chronic kidney disease, multiple cancers (endometrial, esophageal, liver, kidney, breast), osteoarthritis, and dementia

A closer study of the reproductive phenotype of -glutamyl transpeptidase deficient mice show that they are hypogonadal and infertile [39]

Phentermine works primarily as a sympathomimetic medication that stimulates the release of norepinephrine in the hypothalamus, the region of the brain that regulates appetite, meal initiation, and reward-driven eating

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