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Effect of once-weekly subcutaneous semaglutide on arterial inflammation in people with type 2 diabetes and cardiovascular disease using PET-MRI: primary results of a randomized, double-blind, placebo-controlled trial

A 2026 review on fat, muscle, and anti-obesity medications made the concern even more explicit: a consistent component of pharmacologic weight loss can include lean body mass, and resistance training is currently the main suggested strategy for preserving skeletal muscle and function during treatment

Serious side effects are rare but may require immediate medical attention

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When you see a semaglutide prescription for 2.4 mg, your healthcare provider and pharmacist ensure the compounded formulation delivers exactly that amount in a single weekly subcutaneous injection using a pen or syringe

These side effects are not usually dangerous and tend to improve as treatment continues