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In the first subgroup (ALC vs placebo), three studies 15,21,23 reported no AEs in either arm, and one 16 found no between-group difference

10.1523/jneurosci.3784-11.2012 J

Several studies have implied that FXR activation relieves intestinal inflammatory state in IBD patients, as well as that colonic inflammation in patients with CD and in rodent models of colitis is linked to diminished expression of FXR mRNA (Vavassori et al., 2009)

In fact, for some patients with PCOS or obesity, weight reduction through GLP-1s may help restore more regular cycles and improve reproductive outcomes

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Some GLP-1 RA are approved for treating type 2 diabetes, some for weight loss, and others for both