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Yao T, Yao YY, Wang JZ, Jiang SM, Li LJ

Ghrelin biology, however, extends well beyond GH: the same signaling system participates in appetite stimulation, gastric motility and acid secretion, glucose and lipid metabolism, sleepwake regulation, learning and memory, and reward pathways

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We showed that H89 or PKA siRNA blocked the protective effects of metformin on PA-induced endothelial dysfunction, suggesting that metformin alone might upregulate PKA signalling

doi: 10.1016/j.chembiol.2020.03.011 89 SunXNiuXChenRHeWChenDKangRet al