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Mayo Clinic plastic surgery fellowship

546,547 Crosstalk between protein homeostasis machineries: a novel perspective on mechanistic intersections and therapeutic implications Maintaining protein homeostasis is an intricate and dynamic process regulated by multiple interconnected cellular pathways, including the heat shock response (HSR), autophagy, mitophagy, the UPS, ERAD, and non-canonical mechanisms such as chaperone-mediated autophagy (CMA) and ribosome-associated quality control (RQC)

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This suggests that the microbiome within OA cartilage may influence the pathogenesis of OA by affecting inflammatory and metabolic processes

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10.1152/japplphysiol.00670.2017 77 GohariS.ReshadmaneshT.KhodabandehlooH.Karbalaee-HasaniA.AhangarH.GohariS.et al (2022)