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Contact your GP if you notice: Significant weakness or fatigue that interferes with daily activities or represents a marked change from baseline Difficulty performing previously manageable tasks such as climbing stairs, carrying shopping, or rising from a chair Rapid weight loss exceeding about 1 kg per week consistently, which may indicate excessive caloric deficit Inability to meet minimum nutritional requirements due to severe appetite suppression or gastrointestinal side effects Muscle pain, cramping, or unusual soreness not related to exercise Falls or balance problems that could indicate muscle weakness Signs of malnutrition including hair loss, brittle nails, or poor wound healing Seek urgent medical attention if you experience: Severe or persistent abdominal pain (possible pancreatitis) Persistent vomiting or signs of dehydration Yellowing of the skin or eyes (jaundice) Your GP may assess: Current medication dose and whether adjustment is appropriate Nutritional adequacy and potential need for dietitian referral Body composition changes through clinical examination Blood tests to exclude other causes of muscle weakness (thyroid function, vitamin D, electrolytes) Whether additional support services are needed NICE recommends ongoing monitoring of patients on weight management medications