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In contrast, cell lines expressing GSTP1 exhibited an unmethylated and transcriptionally active promoter thus confirming a relationship between hypermethylation and repression of GSTP1 expression (Karius et al., 2011)

DEM upregulated total glutathione levels (Figure 2B), which was expected, since expression of GSH producing enzymes such as GCLM is promoted by nuclear Nrf2

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Klein E.A., Thompson I.M., Tangen C.M., Crowley J.J., Lucia M.S., Goodman P.J., Minasian L.M., Ford L.G., Parnes H.L., Gaziano J.M

Some individuals may experience mild discomfort at the injection site, a warm sensation during the infusion and/or lightheadedness