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Patient-reported outcomes of glucagon-like peptide-1 agonists on hidradenitis suppurativa severity

Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]

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This may explain the total exhaustion experienced by a person suffering from mental fatigue, when being too active and doing too many things. Rnnbck and Hansson propose an inflammatory state where the efficient transmission of information via glutamate is disrupted with a decrease in the ability to discriminate signal from noise

doi: 10.1016/j.bbadis.2020.165768 35 CabreraC