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The distinct features manifested by R310 6.40b and H363 6.52b are likely to be responsible for the kink formation induced by compound 2, in line with previous mutagenesis results that mutation at these two sites altered GLP-1R signaling profiles (cAMP, pERK and iCa 2+ ) 4,37

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Thermostability ( T 50 ) The kinetic thermostability of purified LacAnc100 and LaccID was estimated by assessing their T 50 values using 96-well gradient thermocyclers (T100 thermal cycler, Bio-Rad)

Koou SY, Chong CS, Vythilingam I, Ng LC, Lee CY

Endometriosis: etiology, pathobiology, and therapeutic prospects