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Oral spironolactone is a is potassium-sparing diuretic used off-label in the treatment of hormonal acne and female pattern baldness

Nayan SI, Chowdhury FI, Akter N et al (2021) Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

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This is why baseline and ongoing lab work is so important

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GLP-1 receptors sit in the heart muscle itself