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The prognosis for individuals with cutaneous melanoma depends on the depth and location of the initial tumor, as well as whether or not they have localized or distant metastatic disease

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Int J Cancer Res Ther

[113] demonstrated that in the eyes of aged mice, the increased signaling of the STAT3 pathway induced the M2 polarization of macrophages, thus enhancing vascular proliferation and subsequently the formation of angiogenesis

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