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10.1016/j.drudis.2015.05.009 58 StockwellB

Landscape of transcription in human cells

However, Tirzepatide has a unique advantage: it also activates GIP (Gastric Inhibitory Polypeptide) receptors, enhancing glycemic control by increasing insulin sensitivity and lipid (fat) metabolism

S.BookheimerT.et al (2023)

This leads to the subsequent cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)