Vitamin B12 is a cofactor for L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA in the degradation of propionate, an essential biochemical reaction in fat and protein metabolism
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it preferentially catalyzes only the reaction between D--HB and acetoacetic acid (ACAC)
In the US, diabetes is the most common reason for end-stage renal disease (ESRD), and is responsible for 40% of new dialysis patients
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If youre deficient, your doc may recommend you take about 1,000 to 2,000 mcg of vitamin B12