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In the model, treatment with a MO methanolic extract markedly reduced the serum concentration of C-reactive protein, prostaglandin E2, and TNF, markedly downregulated the levels of NF-B, prostaglandin E2 (PGE2), cyclooxygenase 2 (COX-2), and IL-1, and significantly upregulated the mRNA levels of I-B , IL4 , and IL-10 , and remarkably restored the histopathological indices and arthritic index in the joints (Saleem et al., 2019)

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Typically, fish oil is best for rheumatoid arthritis or RA but has shown benefits for OA as well

further notes that B12 injectables should be made available over the counter at pharmacies, which would bring our approach in line with that of other countries, affording those with B12 deficiency the same dignity and control over their own health as a diabetic using insulin, and reducing the workload and financial burden on GP practices, District Nurses and other NHS services