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Natural age-related fat loss occurs over decades, but rapid weight loss can mimic or speed up this process

Biomedicines 11 , 789 (2023)

Everything in Protocol 1, plus: Protein supplement: Increase to 1.6-2.0 g/kg total daily protein (likely requires 40-80 grams from supplements) Creatine monohydrate: 5 grams daily HMB: 3 grams daily Omega-3 fish oil: 1-2 grams EPA/DHA daily Expected benefits: Significantly reduced lean mass loss, maintained or improved strength, better metabolic rate preservation, improved body composition outcomes

Materials and methods Subjects A total of 100 subjects were recruited in the study from the Outpatient Clinic of Endocrinology in Renji hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China (ChiCTR2300079184)

In particular, the positive impact on maximal effect (E max ) in this assay format significantly improves the chances of identifying weak agonists during high-throughput screening (HTS)

It is currently in Phase 2 trials