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This broad growth factor modulation may create a more favorable environment for tissue recovery and cellular function
Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31
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da CostaRMRodriguesDPereiraCASilvaJFAlvesJVLobatoNSet alNrf2 as a potential mediator of cardiovascular risk in metabolic diseases