Overall, only phentermine and its derivatives as well as orlistat were available and used for weight management
Figure 4 In the context of gout, a decrease in BA levels leads to attenuated FXR activity, consequently diminishes the inhibitory effect on NLRP3 and NF-B signaling pathways and promotes enhanced activity and expression of intestinal XOD, thereby triggering inflammatory responses and elevated UA levels, which exacerbate the progression of gout ( Figure 4 )
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It also acts as an excitatory neurotransmitter and plays a significant role in the sleep-wake cycle
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