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A study done with the average follow up time of around 6 years including 214,998 individuals showed an increased risk of ischemic stroke and myocardial infarctions accompanying long term PPI use (Sehested et al

JACC Basic Transl Sci 3:844857 Schreck R, Rieber P, Baeuerle PA (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

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