In the SURMOUNT-1 trial published in the New England Journal of Medicine, participants taking Zepbound achieved remarkable average weight reductions: 15% (34 lbs) at the 5mg dose, 19.5% (43 lbs) at 10mg, and 20.9% (approximately 48 lbs) at the highest 15mg dose over 72 weeks
Gastrointestinal symptoms such as nausea, bloating, or changes in appetite tend to be the most commonly reported effects during early stages of gradual treatment adjustment, and providers generally expect some of this during the initial phase
They were primarily prescribed for diabetes at first, but many patients have started to turn to them for additional uses that include cardiovascular health and especially weight loss
In participants with type 2 diabetes receiving the 8mg weekly dose, baseline A1C averaged 8.1%
The GLP-1 Nausea Timeline: Why Nausea Often Fluctuates Nausea is one of the most recognizable GLP-1 side effects
* Note on Methodology: Savings figures based on January, February and March 2026 data from employers enrolled in Noom Med with SmartRx across a client population of 24,638 members, of which 367 utilized GLP-1 medications in 2025, as reported directly by the employer
