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Fontes: Antonio Herbert Lancha Junior , coordenador do Laboratrio de Nutrio e Metabolismo da Escola de Educao Fsica e Esporte da USP (Universidade de So Paulo)

[18] [19] Lifestyle modification including dietary change and increased physical activity remains the cornerstone of MASLD/NAFLD management per NICE guideline NG49, but many patients struggle to achieve or sustain sufficient weight loss through lifestyle measures alone

Calcium-independent phospholipase A2 (iPLA2)-mediated lipid peroxidation detoxification is sufficient to inhibit p53-driven ferroptosis under ROS-induced stress and acts as a major ferroptosis suppressor independent of GPX4, suggesting that iPLA2 is a promising therapeutic tumor target (68)

The anti-inflammatory cytokine IL-10 increased, while pro-inflammatory cytokines decreased (IL-6, IL-17, TNF-, and IL-1) (68)

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