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Similarly, in the human chondrocyte SW1353 cell line, dulaglutide inhibited AGEs-induced activation of NFkB and the expression of pro-inflammatory cytokines [99], whilst in human knee OA primary articular chondrocytes, lixisenatide reduced mRNA ad protein expression of TNF-, IL-6 and IL-7 [100]

Castellano-Castillo, D

To model biotinylated cysteine, a residue was initially parameterized with the General Amber Force Field (GAFF) via OpenMMs residue template generator, then modified to incorporate partial charges from the disulfide-bonded cysteine CYX residue and protein parameters from Amber ff14SB 44