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therefore, Nox inhibitors are emerging as potential therapeutics for CKD [60]
Oral semaglutide at doses of 7 and 14 mg/day reduced HbA1c and body weight across the entire spectrum of DM2, as well as other endpoints, such as fasting blood glucose
Response and dosing do not seem to be weight related
It enhances insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite, and improves energy efficiency
A 2021 randomized controlled trial published in Diabetes Care (N=105) compared dulaglutide 1.5 mg weekly against glimepiride over 24 weeks in adults with type 2 diabetes and found that dulaglutide significantly reduced plasma malondialdehyde (a lipid peroxidation marker) and raised superoxide dismutase activity
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