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The opposite effect occurs at the adult stage (P56P70), during which wild-type mice show robust LTP and LTD compared to MET cKO mice in which LTP and LTD are markedly decreased

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Clinical melanin assessments were paired with controlled light exposure, and community-reported protocols consistently pair injections with brief, gradual UV

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Most patients maintain steady weight loss and metabolic benefits over years without needing escalating doses

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