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Skin laxity related to the use of GLP-1 receptor agonists is now a primary concern in aesthetic medicine, according to Macrene Alexiades, MD, PhD, FAAD, director and founder of the Dermatology & Laser Center of New York and a Healio Dermatology Peer Perspective Board Member

FDA and European Medicines Agency (EMA) have concluded that there is no direct evidence for the association of the use with GLP-1RAs with pancreatitis or pancreatic cancer

Neurology (2010) 75(22):19827

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That study showed that, for people with overweight or obesity taking a GLP-1, the risk of the incident (new occurrence) of suicidal ideation is almost 75% lower, and the risk of it happening again (recurrence) is over 50% lower