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Bone Density: Mouse model studies have also linked IGF-1 signaling to improvements in bone density and skeletal strength, suggesting systemic health benefits beyond just muscular development

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The dual receptor agonism could, therefore, counteract the two pathogenetic mechanisms of T2DM (adiposity-induced insulin resistance and pancreatic insulin deficiency) more effectively than selective mono-agonists [163]

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These groups frequently receive additional medications that independently contribute to hyperglycaemia, thereby confounding the observed effects